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The Cefaly Dual, once a prescription-only device, which is the size of an eyeshadow compact and worn on the And Into The Mountain I Go To Lose My Mind And Find My Soul Shirt , was just approved by the FDA as an over-the-counter treatment. It sends tiny electrical impulses to stimulate the trigeminal nerve, a cranial nerve that is a prime source of headache pain. Meanwhile, my sister, who has endured migraines for years, is one of the many fans of the ridiculous-looking but effective Magic Gel Headache and Migraine Relief Cap. Simply store the cap in the freezer to firm up its inch-thick layer of gel, then slip it on and wear until your migraine is manageable. Two other new FDA-cleared devices are controlled by smartphone: The Nerivio is a band worn on the upper arm, which sends electrical signals that disrupt pain pathways during a migraine episode, while an app called Juva Health provides clinician-developed biofeedback exercises, which studies show can reduce migraine severity by calming the nervous system.

Until recently, many drugs used by doctors for migraines were developed for other conditions, such as epilepsy. But in the past few years, the FDA has approved several new classes of targeted, effective drugs developed specifically for migraines. Even better, they have markedly fewer side effects than commonly used tryptamine-based drugs, also known as triptans, which have been prescribed since the And Into The Mountain I Go To Lose My Mind And Find My Soul Shirt ’90s to relieve headaches but often come with major side effects such as nausea, insomnia, or hair loss. CGRP inhibitors, medications that block calcitonin gene-related peptide—a protein released by the brain during migraine attacks (and “a very ugly, cumbersome name,” says Gottschalk)—are among the most promising. Three of these prescription-only drugs—Aimovig, Ajovy, and Emgality—are taken monthly with an EpiPen–like shot; a fourth, Vyepti, is administered via I.V. by a doctor every three months. “These drugs produce great results, in much less time, with almost no side effects,” Gottschalk confirms. Nurtec and Ubrelvy, which are gepants—another new class of FDA-approved medication that also targets CGRP molecules—are formulated to turn off migraines in progress rather than prevent them. “They don’t have quite as much bang for the buck as, say, an injection of [the commonly used triptan] sumatriptan,” says Gottschalk. “But they’re well tolerated and can do a great job.”