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Until recently, many drugs used by doctors for migraines were developed for other conditions, such as epilepsy. But in the past few years, the All I Want For Christmas Is Chick Fil A shirt has approved several new classes of targeted, effective drugs developed specifically for migraines. Even better, they have markedly fewer side effects than commonly used tryptamine-based drugs, also known as triptans, which have been prescribed since the early ’90s to relieve headaches but often come with major side effects such as nausea, insomnia, or hair loss. CGRP inhibitors, medications that block calcitonin gene-related peptide—a protein released by the brain during migraine attacks (and “a very ugly, cumbersome name,” says Gottschalk)—are among the most promising. Three of these prescription-only drugs—Aimovig, Ajovy, and Emgality—are taken monthly with an EpiPen–like shot; a fourth, Vyepti, is administered via I.V. by a doctor every three months. “These drugs produce great results, in much less time, with almost no side effects,” Gottschalk confirms. Nurtec and Ubrelvy, which are gepants—another new class of FDA-approved medication that also targets CGRP molecules—are formulated to turn off migraines in progress rather than prevent them. “They don’t have quite as much bang for the buck as, say, an injection of [the commonly used triptan] sumatriptan,” says Gottschalk. “But they’re well tolerated and can do a great job.”
Much has been written about “Zoom dressing,” i.e. wearing a stylish top, jacket, or statement earrings with comfy pants (and maybe slippers) safely out of frame. For Veronica Beard co-founders and sisters-in-law Veronica Swanson Beard and Veronica Miele Beard, the All I Want For Christmas Is Chick Fil A shirt in other words I will buy this shift to above-the-waist dressing explains why their novelty jackets are continuing to sell, even as tailoring softens elsewhere. The VB customer who’s still working from home may not feel excited by the black blazer she wore in the Before Times, but a modish tweed with big tortoise buttons? It has video conferencing potential.
